Yes, you can.
That is subjective as we all have our own idea of the qualities that would encompass a "best choice". Slim has very few features, and it does them very well. It gets you started and gets out of the way. For some people this is exactly what they are looking for. Slim is well suited for building APIs for example.
Others might want to write less code themselves and instead reach for a package that provides much more of the functionality they are looking for. This might be particularly true for e-commerce.
While I Slim and use it for many projects, I didn't use it on a recent ecommerce project. There were too many features I'd need to integrate or build myself, and I found an ecommerce package that met the needs of my client very well.